Klonopin is a drug supplied to treat scare disorder and certain types of seizures. It has actually a lengthy half-life and can remain in a person’s system for weeks.

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In studies, Klonopin was detectable top top a urine check for as much as a month, top top a hair check for up to 28 days, and on a saliva test for as much as 5 or 6 days.

Abuse of Klonopin have the right to lead come addiction and physical dependence. People who have become dependent top top the drug must work v a physician or addiction treatment regimen to slowly reduce the dose (taper), as preventing abruptly deserve to be dangerous and also even life-threatening.


How Is Klonopin Used?

Clonazepam, likewise known by the brand surname Klonopin, is a prescription sedative medication offered to treat panic disorder and also seizure disorders. Specifically, the is aimed at treating Lennox-Gastaut syndrome, akinetic, and also myoclonic seizures.1

Klonopin is in the benzodiazepine course of drugs and is believed to achieve its impacts by improving the activity of the neurotransmitter gamma-aminobutyric acid (GABA), i m sorry is the key inhibitory neurotransmitter in the brain.1

What are the Effects?

The intended effect of Klonopin is to mitigate the occurrence of seizures or scare attacks. In spite of its therapeutic benefits, use of the medicine may have some side effects, including:2

Feelings the tirednessDepression (mostly discovered in adults).Irritability.Dizziness.Coordination and balance issues.Problems v concentration.Memory and also attention problems.Nausea.Loss that appetite.

Serious side results include:3

Increased love rate.Low blood pressure.Respiratory depression.Difficulty breathing.Drowsiness.Impaired speaking.Loss of consciousness.Loss of satisfied (anhedonia).Depressed mood.Suicidal ideation.

According come the national Alliance on Mental disease (NAMI), plenty of drugs may connect with Klonopin.

Concurrent use of ketoconazole, itraconazole, nefazodone, fluvoxamine, and also cimetidine may boost the blood levels and also effects of clonazepam.3Concurrent usage of carbamazepine, phenytoin, and phenobarbital may decrease level of the drug, making Klonopin much less effective.3

Combining Klonopin and other benzodiazepines, alcohol, and opioids can lead come slowed breathing, coma, and death.


Likewise, combining Klonopin with alcohol, sleeping pills, opioids, anti-anxiety medications, antipsychotic medications, various other anticonvulsants, antidepressants, and antihistamines can reason increased drowsiness. Combining Klonopin and other benzodiazepines, alcohol, and opioids can additionally lead to slowed breathing, coma, and also death.3

In enhancement to enduring adverse side effects, it is possible to overdose from acquisition too much clonazepam—and this threat is enhanced when the is merged with alcohol and also other drugs. If you watch someone suffering an overdose, contact for emergency medical aid right away.

Signs and also symptoms the overdose include:1

Poor reflexes.Confusion.Extreme drowsiness.Coma.

Flumazenil is a medicine that can partially or fully reverse the effects of a clonazepam overdose. However, that is supplied in emergency setups as a component of overdose treatment and not together a substitute because that it. By blocking the benzodiazepine result of clonazepam, flumazenil management could an outcome in seizures in susceptible patients—so it will be administered by the emergency team v caution.1


How lengthy Does It continue to be in her Body?

Due to its long half-life the 20-50 hours, clonazepam continues to be in the body because that a much longer time than various other drugs with reasonably shorter half-lives. The half-life the a drug describes the amount of time the takes a person’s body to eliminate fifty percent of the dose.4


The following are some basic timeframes for how long Klonopin will present up top top different species of tests based upon case studies.

It is crucial to note that Klonopin might not show up on usual urine tests. The test may be able to show that the medicine is present, yet it may not have the ability to determine the amount.5

In one study, traces of clonazepam’s significant metabolite 7-aminoclonazepam to be detectable top top a urine check for approximately 3 weeks after ~ a single 3mg dose, and also one the the attendees in the research tested positive 28 days after the last dose. However, the mayo Clinic claims that long-acting benzodiazepines such as clonazepam may be recognize in the urine for approximately 30 days.6,7In one study, 7-aminoclonazepam to be detectable in the hair the 6 the end of 10 participants ~ they take it a solitary 3mg dose. In 2 participants, it was detectable because that 28 days. In 2 participants, it to be detectable top top the 21st day, and also in 2 participants, it to be detectable ~ above the 28th day.8Saliva tests have actually a detection home window of as much as 5 and also 6 days adhering to last use.9


Individual components can influence the result of a test, including:5,7

Age.Gender.Health.Weight.pH of urine.Urine concentration.When the last dose to be taken.Amount taken.Frequency the use.

How execute You detox From Klonopin?

Klonopin is a Schedule IV controlled substance, which way it has actually some potential for abuse and also physical or emotional dependence. Physical dependency can develop after just 2 weeks of acquisition the medicine daily, explains the nationwide Alliance on Mental disease (NAMI). It is feasible to develop some amount of physiological dependence also when acquisition the drug precisely as command by your doctor.3


If you have been abusing Klonopin, a clinical detox regime can help ensure a safe withdrawal.


NAMI alerts that clonazepam use must not be quit abruptly or without talking to your medical professional first. If stopped too abruptly, uncomfortable side effects are likely to occur, and some can also be life-threatening. Withdrawal symptoms include:3,10

Anxiety.Insomnia.Irritability.Dizziness.Sweating.Nausea.Vomiting.Changes in blood pressure.Increased heart rate.Hallucinations.Tremors.Seizures.

Withdrawal symptoms might not develop for more than a week, reach height intensity throughout the second week, and fade during the third or fourth week.10

If you have actually been taking the medication under the care of a physician, you can work with them ~ above a tapering schedule to gradually reduce the dose. The recommended tapering schedule is to decrease the dose by 0.125mg every 3 days until you room no longer taking the drug. However, speak to your medical professional to determine the ideal dose because that you.1

If you have been abusing Klonopin, a medical detox program can help ensure a for sure withdrawal. These programs can help you safely taper off the drug—as fine as any other drugs you have actually been using—and treat any kind of complications that arise.

How easy Is the to become Addicted to Klonopin?

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Though the may have actually somewhat much less abuse potential than drugs such together opioids, cocaine, or methamphetamine, civilization can build an addiction to Klonopin and also other benzodiazepines if they on regular basis abuse them. Many human being abuse castle in mix with other drugs. For example, they might use lock to intensify an opioid high, lull withdrawal native heroin or various other opioids, boost the impacts of alcohol, and self-manage alcohol withdrawal.11

People who end up being addicted come Klonopin and also develop far-ranging physical dependence could require the safety and supervision that a clinical detoxification program complied with by formal seeks treatment. There are countless options obtainable for addiction treatment, consisting of inpatient and also outpatient programs. Program often incorporate individual and group therapy, skill-building sessions, addiction education, medical services, and continuing treatment plans.

Effective therapy programs identify that no solitary treatment will work-related for everyone, and also treatment plans should be personal tailored and also continually reviewed and updated. Treatment must also attend to any co-occurring substance usage or mental wellness disorders in bespeak to stop relapse.12 for example, world who began taking Klonopin for scare disorder and began abusing it require treatment for their panic disorder and also substance abuse. Otherwise, castle may begin abusing building material again if their panic symptoms resurface.

If you’re ready to get assist for an addiction to Klonopin or one more substance, start exploring your alternatives today.

Sources

<1>. Food and Drug Administration. (2017). Klonopin tablets (clonazepam).

<2>. Epilepsy Foundation. Clonazepam.

<3>. Nationwide Alliance on mental Illness. (2019). Clonazepam (Klonopin).

<4>. Epocrates. Clonazepam.

<5>. College of Rochester clinical Center. Benzodiazepines (Urine).

<6>. Negrusz, A. Et al. (2003). Elimination of 7-aminoclonazepam in urine after a single dose of clonazepam. Analytical and also Bioanalytical Chemistry, 376(8).

<7>. Moeller, K., Kissack, J., Atayee, R., and Lee, K. (2017). Clinical interpretation of Urine medicine Tests: What Clinicians have to Know around Urine medicine Screens. Mei Clinic Proceedings.

<8>. Negrusz, A. Et al. (2002). Deposition of 7-Aminoclonazepam and Clonazepam in Hair following a solitary Dose that Klonopin. Journal of analysis Toxicology, 26, 471-478.

<9>. Nordal, K., Oiestad, E.L., Enger, A., Christophersen, A.S., and Vindenes, V. (2015). Detection times of Diazepam, Clonazepam, and Alprazolam in dental Fluid collected From patient Admitted to Detoxification, after ~ High and Repeated drug Intake. Therapeutic medicine Monitoring, 37(4), 451-460.

<10>. American Psychiatric Association. (2013). Diagnostic and also statistical manual of psychological disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.

<11>. Longo, L., and Johnson, B. (2000). Addiction: part I. Benzodiazepines—Side Effects, Abuse Risk and also Alternatives. American family Physician, 61(7), 2121-2128.

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<12>. Nationwide Institute on drug Abuse. (2019). Treatment viewpoints for drug Addiction.