Each 5 mg tablet computer contains 4.5 mg of oxycodone as 5 mg of oxycodone hydrochloride.

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Each 10 mg tablet computer contains 9.0 mg that oxycodone together 10 mg that oxycodone hydrochloride.

Each 15 mg tablet computer contains 13.5 mg of oxycodone as 15 mg that oxycodone hydrochloride.

Each 20 mg tablet contains 18.0 mg of oxycodone together 20 mg the oxycodone hydrochloride.

Each 30 mg tablet computer contains 27 mg the oxycodone as 30 mg that oxycodone hydrochloride.

Each 40 mg tablet contains 36.0 mg the oxycodone as 40 mg of oxycodone hydrochloride.

Each 60 mg tablet computer contains 54 mg that oxycodone as 60 mg that oxycodone hydrochloride.

Each 80 mg tablet computer contains 72.0 mg that oxycodone as 80 mg that oxycodone hydrochloride.

Each 120 mg tablet computer contains108 mg that oxycodone as 120 mg the oxycodone hydrochloride.

Excipient with recognized effect:

Contains lactose monohydrate.

For the full list of excipients, see ar 6.1.


3. Pharmaceutical form

Prolonged release tablet.

The 5 mg tablets are light blue, round, convex tablets significant OC top top one side and 5 top top the other.

The 10 mg tablets space white, round, convex tablets significant OC on one side and also 10 on the other.

The 15 mg tablets room grey, round, convex tablets marked OC top top one side and also 15 ~ above the other.

The 20 mg tablets are pink, round, convex tablets marked OC top top one side and 20 top top the other.

The 30 mg tablets are brown, round, convex tablets marked OC ~ above one side and 30 top top the other.

The 40 mg tablets are yellow, round, convex tablets marked OC top top one side and 40 on the other.

The 60 mg tablets are red, round, convex tablets significant OC ~ above one side and also 60 on the other.

The 80 mg tablets are green, round, convex tablets significant OC on one side and also 80 on the other.

The 120 mg tablets space purple, round, convex tablets marked OC on one side and 120 ~ above the other.


4. Clinical particulars
4.1 Therapeutic indications

For the treatment of center to significant pain in patients v cancer and post-operative pain. For the treatment of significant pain inquiry the use of a strong opioid.


4.2 Posology and an approach of administration

Adults end 18 years:

OxyContin tablets must be taken in ~ 12-hourly intervals. The dosage is dependence on the severity of the pain, and also the patient"s previous history of analgesic requirements.

Prior to beginning treatment with opioids, a discussion should be held with patients to put in ar a strategy for ending treatment with oxycodone in order to minimise the hazard of addiction and drug tap the money syndrome (see ar 4.4).

OxyContin is no intended for use as a prn analgesic.

Generally, the lowest reliable dose for analgesia must be selected. Boosting severity of ache will require an enhanced dosage of OxyContin tablets, using the different tablet computer strengths, one of two people alone or in combination, to attain pain relief. The exactly dosage for any individual patience is the which controls the pain and is fine tolerated for a full 12 hours. Patients must be titrated to pain relief uneven unmanageable adverse medicine reactions stop this. If higher doses room necessary, rises should it is in made in 25% - 50% increments. The require for escape medication more than twice a day shows that the dosage the OxyContin tablets have to be increased.

The usual starting dose for opioid naïve patient or patients presenting with major pain untreated by weaker opioids is 10 mg, 12-hourly. Part patients may advantage from a starting dose that 5 mg come minimise the incidence of side effects. The dose have to then be very closely titrated, as commonly as when a day if necessary, to accomplish pain relief.

Conversion from oral morphine:

Patients receiving dental morphine before OxyContin treatment should have actually their everyday dose based on the complying with ratio: 10 mg of dental oxycodone is tantamount to 20 mg of dental morphine. It need to be emphasised that this is a overview to the dose of OxyContin tablet computers required. Inter-patient variability requires that each patient is very closely titrated come the suitable dose.

Transferring patients in between oral and parenteral oxycodone:

The dose must be based upon the complying with ratio: 2 mg of oral oxycodone is tantamount to 1 mg the parenteral oxycodone. It should be emphasised the this is a guide to the dose required. Inter-patient variability requires that each patient is closely titrated come the ideal dose.

Elderly patients:

A sheep adjustment is not usually crucial in yonsi patients.

Controlled pharmacokinetic studies in elderly patient (aged end 65 years) have displayed that, compared with younger adults, the clearance of oxycodone is just slightly reduced. No untoward adverse drug reactions to be seen based on age, as such adult doses and also dosage intervals space appropriate.

Paediatric population

OxyContin should not be offered in patients under 18 year of age.

Patients through renal or hepatic impairment:

The plasma concentration in this population may be increased. The sheep initiation must follow a conservative strategy in these patients. The recommended adult beginning dose have to be diminished by 50% (for example a full daily sheep of 10 mg orally in opioid naïve patients), and also each patient need to be titrated to sufficient pain manage according to your clinical situation.

Use in non-malignant pain:

Opioids space not first-line therapy for chronic non-malignant pain, nor room they recommended together the just treatment. Varieties of chronic ache which have been displayed to it is in alleviated by solid opioids encompass chronic osteoarthritic pain and intervertebral key disease. The require for ongoing treatment in non-malignant pain should be assessed at continuous intervals.

Method of administration

OxyContin tablets are for oral use.

OxyContin tablets should be swallowed whole and also not broken, chewed or crushed.

Duration that treatment

Oxycodone need to not be offered for longer than necessary.

Discontinuation the treatment

When a patient no longer requires therapy with oxycodone, it may be advisable to taper the dose slowly to prevent symptoms that withdrawal.


Hypersensitivity come oxycodone or to any kind of of the excipients listed in section 6.1.

Oxycodone should not be used in any type of situation wherein opioids room contraindicated: serious respiratory depression through hypoxia, paralytic ileus, acute abdomen, delay gastric emptying, major chronic obstructive lung disease, cor pulmonale, major bronchial asthma, elevated carbon dioxide level in the blood, middle to severe hepatic impairment, chronic constipation.

Patients v rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption need to not take it this medicine.


Caution should be exercised when administering oxycodone to the debilitated elderly, patients v severely impaired pulmonary function, patients v impaired hepatic or renal function, patients with myxoedema, hypothyroidism, Addison"s disease, toxic psychosis, prostate hypertrophy, adrenocortical insufficiency, alcoholism, delirium tremens, illness of the biliary tract, pancreatitis, inflammatory bowel disorders, hypotension, hypovolaemia raised intracranial pressure, intracranial lesions, head injury (due to risk of increased intracranial pressure), lessened level of awareness of uncertain origin, sleep apnoea or patients acquisition benzodiazepines, other CNS depressants (including alcohol) or MAO inhibitors (see section 4.5).

The main risk that opioid overfill is respiratory depression.

Opioids may cause sleep-related breathing disorders including central sleep apnoea (CSA) and sleep-related hypoxemia. Opioid use may rise the hazard of CSA in a dose-dependent path in part patients. Opioids may also cause worsening that pre-existing sleep apnoea (see section 4.8). In patients who existing with CSA, think about decreasing the total opioid dosage.

Concomitant usage of oxycodone and also sedative smashville247.net such as benzodiazepines or connected drugs may an outcome in sedation, respiratory tract depression, coma and death. Since of this risks, concomitant prescribing with these sedative smashville247.net must be booked for patients because that whom alternative treatment alternatives are not possible.

If a decision is made come prescribe oxycodone concomitantly through sedative smashville247.net, the lowest reliable dose have to be used, and also the duration of treatment must be as short as possible (see also general dose recommendation in section 4.2).

The patient have to be followed carefully for signs and symptoms of respiratory tract depression and also sedation. In this respect, the is strong recommended to educate patients and also their caregivers to be mindful of these symptoms (see ar 4.5).

OxyContin tablets have to be administered with caution in patients taking MAOIs or who have actually received MAOIs in ~ the previous two weeks.

OxyContin tablets need to not be used where over there is a opportunity of paralytic ileus occurring. Have to paralytic ileus be doubt or occur during use, OxyContin tablets should be stop immediately.

OxyContin tablets space not recommended for pre-operative usage or within the first 12-24 hours post-operatively.

As v all opioid preparations, oxycodone commodities should be offered with caution following abdominal surgery together opioids are well-known to dilute intestinal motility and should no be used until the doctor is assured of normal bowel function.

Patients around to undergo additional pain relieving steps (e.g. Surgery, plexus blockade) should not obtain OxyContin tablets for 12 hrs prior come the intervention. If more treatment through OxyContin tablets is indicated then the dosage have to be changed to the new post-operative requirement.

OxyContin 60 mg, 80 mg and also 120 mg tablets must not be offered in patients not previously exposed come opioids. These tablet strengths may cause fatal respiratory tract depression when administered to opioid naïve patients.

For suitable patients who suffer with chronic non-malignant pain, opioids have to be provided as part of a considerable treatment programme entailing other medications and also treatment modalities. A crucial part of the evaluate of a patient with chronic non-malignant ache is the patient"s addiction and also substance abuse history.

If opioid therapy is considered ideal for the patient, climate the key aim of treatment is no to minimise the dose of opioid however rather to accomplish a sheep which offers adequate pains relief v a minimum of side effects. There need to be regular contact in between physician and patient so that dosage adjustments have the right to be made. The is strong recommended the the physician defines treatment outcomes in accordance v pain monitoring guidelines. The physician and patient deserve to then agree come discontinue therapy if these goals are not met.

Drug dependence, tolerance and potential for abuse

For all patients, lengthy use the this product may cause drug dependence (addiction), also at therapeutic doses. The risks are raised in individuals with current or past history of substance misuse disorder (including alcohol misuse) or mental health and wellness disorder (e.g. Major depression).

Additional support and monitoring might be essential when prescribing for patients at danger of opioid misuse.

A considerable patient background should it is in taken to paper concomitant medications, including over-the-counter smashville247.net and also smashville247.net acquired on-line, and past and also present medical and also psychiatric conditions.

Patients may find that therapy is less effective with chronic use and express a require to increase the dose to acquire the very same level that pain manage as at first experienced. Patients may additionally supplement their treatment with added pain relievers. These could be indicators that the patient is emerging tolerance. The risks of arising tolerance must be defined to the patient.

Overuse or misuse may an outcome in overdose and/or death. The is crucial that patients just use smashville247.net that space prescribed for them in ~ the sheep they have been prescribed and do not offer this medicine to everyone else.

Patients have to be closely monitored for signs of misuse, abuse or addiction.

The clinical need for analgesic treatment must be the evaluation regularly.

Drug withdrawal syndrome

Prior to starting treatment with any type of opioids, a conversation should be held with patient to put in place a withdrawal strategy for ending treatment through oxycodone.

Drug tap the money syndrome may occur upon abrupt cessation of therapy or sheep reduction. As soon as a patience no longer requires therapy, it is advisable to taper the dose progressively to minimise symptoms of withdrawal. Tapering native a high dose may take weeks to months.

The opioid medicine withdrawal syndrome is characterised by part or every one of the following: restlessness, lacrimation, rhinorrhoea, yawning, perspiration, chills, myalgia, mydriasis and palpitations. Other symptoms may additionally develop consisting of irritability, agitation, anxiety, hyperkinesia, tremor, weakness, insomnia, anorexia, ab cramps, nausea, vomiting, diarrhoea, increased blood pressure, boosted respiratory price or love rate.

If women take this drug throughout pregnancy there is a danger that their newborn babies will experience neonatal tap the money syndrome.

Hyperalgesia

Hyperalgesia might be diagnosed if the patient on irreversible opioid treatment presents with raised pain. This can be qualitatively and also anatomically distinctive from pain associated to condition progression or to breakthrough pain result from development of opioid tolerance. Pain connected with hyperalgesia tends to be an ext diffuse 보다 the pre-existing pain and also less characterized in quality. Symptom of hyperalgesia might resolve v a reduction of opioid dose.

OxyContin tablets have to be swallowed whole, and also not broken, chewed or crushed. The management of broken, chewed, or crushed OxyContin tablet computers leads come a rapid release and absorption the a perhaps fatal dose of oxycodone (see ar 4.9).

Concomitant use of alcohol and also OxyContin may boost the undesirable effects of OxyContin; concomitant use have to be avoided.

Abuse of oral dosage develops by parenteral administration can be supposed to result in severe adverse events, together as regional tissue necrosis, infection, pulmonary granulomas, boosted risk that endocarditis, and also valvular love injury, which may be fatal.

Empty procession (tablets) might be viewed in the stools.

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Opioids such as oxycodone hydrochloride may affect the hypothalamic-pituitary-adrenal or – gonadal axes. Some alters that can be seen include rise in serum prolactin, and also decreases in plasma cortisol and also testosterone. Clinical symptoms may manifest indigenous these hormone changes.